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- Description:
- National aggregation of patient care reports associated with 9-1-1 activations for emergency care. Go to www.nemesis.org for details.
- Keyword:
- national data, pre-hospital, paramedic, Emergency Medical Services, 9-1-1, Emergency Care, and 911
- Subject:
- Emergency Medical Care
- Creator:
- Office of EMS, U.S. Department of Transportation, and National Highway Safety Administration
- Contributor:
- NEMSIS Technical Assistance Center
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- United States, , United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/16/2024
- Date Created:
- 2015-01-01 to 2015-12-31
- License:
- Other – See README file for more information.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5SX6BC3
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- Description:
- Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
- Keyword:
- pharmacokinetics, tibia, infections, systematic toxicity, bone, antibiotics, rat, osteomyelitis, and vancomycin
- Subject:
- Infectious Diseases
- Creator:
- Loc-Carrillo, Catherine
- Contributor:
- Wu, Sijia, Fernandez, Sheena, Burr, Michael, Fredricksen, Hunter, Canden, Ahranee, Hoerger, Kelly, Churchill, John, Wang, Caroline, and Agarwal, Jay
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/16/2024
- Date Created:
- 2013-05-01 to 2015-01-30
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5W0942B